Tissue Mechanics

The structures of living tissues are continually changing due to growth and response to the tissue environment, including the mechanical environment. Tissue Mechanics is an in-depth look at the mechanics of tissues. Tissue Mechanics describes the nature of the composite components of a tissue, the cellular processes that produce these constituents, the assembly of the constituents into a hierarchical structure, and the behavior of the tissue’s composite structure in the adaptation to its mechanical environment. Organized as a textbook for the student needing to acquire the core competencies, Tissue Mechanics will meet the demands of advanced undergraduate or graduate coursework in Biomedical Engineering, as well as, Chemical, Civil, and Mechanical Engineering. Key features: Detailed Illustrations Example problems, including problems at the end of sections A separate solutions manual available for course instructors A website (http://tissue-mechanics.com/) that has been established to provide supplemental material for the book, including downloadable additional chapters on specific tissues, downloadable PowerPoint presentations of all the book's chapters, and additional exercises and examples for the existing chapters. About the Authors: Stephen C. Cowin is a City University of New York Distinguished Professor, Departments of Biomedical and Mechanical Engineering, City College of the City University of New York and also an Adjunct Professor of Orthopaedics, at the Mt. Sinai School of Medicine in New York, New York. In 1985 he received the Society of Tulane Engineers and Lee H. Johnson Award for Teaching Excellence and a recipient of the European Society of Biomechanics Research Award in 1994. In 1999 he received the H. R. Lissner medal of the ASME for contributions to biomedical engineering. In 2004 he was elected to the National Academy of Engineering (NAE) and he also received the Maurice A. Biot medal of the American Society of Civil Engineers (ASCE). Stephen B. Doty is a Senior Scientist at Hospital for Special Surgery, New York, New York and Adjunct Professor, School of Dental and Oral Surgery, Columbia University, New York, NY. He has over 100 publications in the field of anatomy, developmental biology, and the physiology of skeletal and connective tissues. His honors include several commendations for participation in the Russian/NASA spaceflights, the Spacelab Life Science NASA spaceflights, and numerous Shuttle missions that studied the influence of spaceflight on skeletal physiology. He presently is on the scientific advisory board of the National Space Biomedical Research Institute, Houston, Texas.

This special volume of the Journal of Elasticity represents the first in a new p- gram dedicated to the occasional publication of collections of invited, reviewed papers of topical interest. The purpose of this program is to spotlight the dev- opments and applications in the mechanics of materials within specific areas that can enhance growth and provide insight for the advancement of the field as well as promote fundamental understanding and basic discovery. Soft Tissue Mechanics is an area of biomechanics that draws heavily upon f- damental ideas and material models from nonlinear elasticity and viscoelasticity. A major goal of this research is to understand those mechanics properties of heart, artery, collagen and skeletal muscle tissue that can be used for the diagnosis of health problems and the improvement of human life. This volume illustrates how experiment, modeling and computation is currently employed in this emerging field. May 2001 ROGER FOSDICK Editor-in-Chief Journal of Elasticity 61: ix–xii, 2000. ix Preface There are two primary areas for the application of elasticity in the biomechanics of tissues: hard tissue mechanics (e.g., bone, teeth, horns, etc.) and soft tissue - chanics (e.g., skin, tendons, arteries, etc.). The distinguishing feature between these tissue types is the amount of physiological “normal” deformation they experience. While “hard” tissues only experience small deformations, soft tissues typically experience large deformations. From a biomechanics viewpoint soft tissues fall within the realm of finite elasticity.

This textbook describes the biomechanics of bone, cartilage, tendons and ligaments. It is rigorous in its approach to the mechanical properties of the skeleton yet it does not neglect the biological properties of skeletal tissue or require mathematics beyond calculus. Time is taken to introduce basic mechanical and biological concepts, and the approaches used for some of the engineering analyses are purposefully limited. The book is an effective bridge between engineering, veterinary, biological and medical disciplines and will be welcomed by students and researchers in biomechanics, orthopedics, physical anthropology, zoology and veterinary science. This book also: Maximizes reader insights into the mechanical properties of bone, fatigue and fracture resistance of bone and mechanical adaptability of the skeleton Illustrates synovial joint mechanics and mechanical properties of ligaments and tendons in an easy-to-understand way Provides exercises at the end of each chapter

The invited papers in this book reflect the current understanding of the role mechanics play in the biological system at the molecular, cellular and tissue levels. Topics range from tissue engineering and mechanics to mechanics of cells and biomolecules.

The mechanics of biological tissues is a multidisciplinary and rapidly expanding area of research. This book points to important directions combining mechanical sciences with the new developments in biology. It delivers articles on mechanics of tissues at the molecular, cellular, tissue and organ levels.

This book describes these exciting new developments, and presents experimental and computational findings that altogether describe the frontier of knowledge in cellular and biomolecular mechanics, and the biological implications, in health and disease. The book is written for bioengineers with interest in cellular mechanics, for biophysicists, biochemists, medical researchers and all other professionals with interest in how cells produce and respond to mechanical loads.

As a reference book, the Springer Handbook provides a comprehensive exposition of the techniques and tools of experimental mechanics. An informative introduction to each topic is provided, which advises the reader on suitable techniques for practical applications. New topics include biological materials, MEMS and NEMS, nanoindentation, digital photomechanics, photoacoustic characterization, and atomic force microscopy in experimental solid mechanics. Written and compiled by internationally renowned experts in the field, this book is a timely, updated reference for both practitioners and researchers in science and engineering.

Developments in tissue engineering for human medicine are increasing rapidly. Advances in stem cell biology, biomaterials science and scaffold design underpin this emerging science. An equally important facet of this field is the rational design and operation of bioreactors to control the nascent tissue growth. For the first time in a single volume, the design, characterisation and operation of the bioreactor system in which the tissue is grown is detailed. Bioreactors for Tissue Engineering presents an overall picture of the current state of knowledge in the engineering of bioreactors for several tissue types (bone, cartilage, vascular), addresses the issue of mechanical conditioning of the tissue, and describes the use of techniques such as MRI for monitoring tissue growth. This unique volume is dedicated to the fundamentals and application of bioreactor technology to tissue engineering products. Not only will it appeal to graduate students and experienced researchers in tissue engineering and regenerative medicine, but also to tissue engineers and culture technologists, academic and industrial chemical engineers, biochemical engineers and cell biologists who wish to understand the criteria used to design and develop novel systems for tissue growth in vitro.

Emerging imaging techniques have opened new fronts to investigate tissues, cells, and proteins. Transformative technologies such as microCT scans, super-resolution microscopy, fluorescence-based tools, and other methods now allow us to study the mechanics of cancer, dissect the origins of cellular force regulation, and examine biological specimens

A modern quantitative study of lung mechanics, relating mathematical modeling and engineering principles to lung function, structure, mechanics, and disease.

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This text presents a general introduction to soft tissue biomechanics. One of its primary goals is to introduce basic analytical, experimental and computational methods. In doing so, it enables readers to gain a relatively complete understanding of the biomechanics of the heart and vasculature.

This text features 105 papers dealing with the fundamentals and the applications of poromechanics from the Biot conference of 1998, held in Louvain-la-Neuve. Topics include: wave propogation; numerical modelling; identification of poromechanical parameters; and constitutive modelling.

The term "neuromechanics" defines an integrative approach that combines the neuromuscular control and the biomechanical aspects of physical behavior in humans and animals. Crucial to this approach is a detailed description and modeling of the interaction between the nervous system and the controlled biomechanical plant. Only then do we have the broader context within which to understand evolution, movement mechanics, neural control, energetics, disability and rehabilitation. In addition to enabling new basic science directions, understanding the interrelations between movement neural and mechanical function should also be leveraged for the development of personalized wearable technologies to augment or restore the motor capabilities of healthy or impaired individuals. Similarly, this understanding will empower us to revisit current approaches to the design and control of robotic and humanoid systems to produce truly versatile human-like physical behavior and adaptation in real-world environments. This Research Topic is therefore poised at an opportune moment to promote understanding of apparently disparate topics into a coherent focus.

Military Injury Biomechanics: The Cause and Prevention of Impact Injuries is a reference manual where information and data from a large number of sources, focussing on injuries related to military events, has been critically reviewed and discussed. The book covers the cause and prevention of impact injuries to all the major body regions, while topics such as the historical background of military impact biomechanics, the history and use of anthropomorphic test devices for military applications and the medical management of injuries are also discussed. An international team of experts have been brought together to examine and review the topics. The book is intended for researchers, postgraduate students and others working or studying defence and impact injuries.

Textbook of Pulmonary Vascular Diseases combines basic scientific knowledge on the pulmonary circulatory system at levels of the molecule, cell, tissue, and organ with clinical diagnosis and treatment of pulmonary vascular diseases. State-of-the-art techniques and their potential applications in research, diagnosis, and treatment of pulmonary vascular diseases are also covered.

Biomechanics as a scientific activity is not new. Already involved (or so it is said) in its practice were Aristotle (384-327 BC) and Leonardo da Vinci (1452-1519). Recently, however, it has become fashionable as a separate field, as witnessed by the existence of a Journal of Biomechanics (1968), an Interna tional (1973), a European (1976) and an American (1977) Society of Biomechanics, and an amount of (usually recently erected) Biomechanics Laboratories at Uni versities or other institutions throughout the world. If one or~anises a Con ference on Biomechanics, a relatively large number of scientists leave their cubicles or workshops to visit the place of worship. It becomes quickly evident, however, that such a forum for scientific communication is far from being homo geneous. All are not of the same believe, and the variety in professional inte rests almost parallels the number of attendants. "Biomechanics, the science of applying methods and principles of Mechanics to biological tissues and medical problems" is a definition which, in one form or another, has found wide acceptance among biomecanicians. Nevertheless, Bio mechanics is interwoven and thus often confused with other scientific endeavors. It is colored differently by its many fields of application (e. g. Orthopaedic and Cardio-Vascular Surgery, Dentistry, Rehabilitation, Physical Medicine, Injury Prevention, Sports and others), and the backgrounds of its disciplina ries. It partly overlaps sciences as Biomaterials, Medical Physics and Biophy sics, Physiology, and Functional Anatomy.