The Collagen Superfamily and Collagenopathies

The Collagen Superfamily and Collagenopathies
  • Author : Florence Ruggiero
  • Publisher : Springer Nature
  • Pages : 338
  • Relase : 2021-05-15
  • ISBN : 9783030675929

The Collagen Superfamily and Collagenopathies Book Review:

This book aims at providing insights into the collagen superfamily and the remarkable diversity of collagen function within the extracellular matrix. Additionally, the mechanisms underlying collagen-related diseases such as dystrophic epidermolysis bullosa, osteogenesis imperfecta, as well as collagen-related myopathies and neurological disorders are discussed. Collagens are the most abundant extracellular matrix proteins in organisms. Their primary function is to provide structural support and strength to cells and to maintain biomechanical integrity of tissues. However, collagens can no longer be considered just as structural proteins. They can act as extracellular modulators of signaling events and serve critical regulatory roles in various cell functions during embryonic development and adult homeostasis. Furthermore, collagens are associated with a broad spectrum of heritability-related diseases known as “collagenopathies” that affect a multitude of organs and tissues including sensorial organs. The book is a useful introduction to the field for junior scientists, interested in extracellular matrix research. It is also an interesting read for advanced scientists and clinicians working on collagens and collagenopathies, giving them a broader view of the field beyond their area of specialization.

Genetic Manipulation of DNA and Protein

Genetic Manipulation of DNA and Protein
  • Author : David Figurski
  • Publisher : IntechOpen
  • Pages : 464
  • Relase : 2013-02-05
  • ISBN : 9535109944

Genetic Manipulation of DNA and Protein Book Review:

This diverse collection of research articles is united by the enormous power of modern molecular genetics. Every author accomplished two objectives: (1) making the field and the research described accessible to a large audience and (2) explaining fully the genetic tools and approaches that were used in the research. One fact stands out - the importance of a genetic approach to addressing a problem. I encourage you to read several chapters. You will feel the excitement of the scientists, and you will learn about an area of research with which you may not be familiar. Perhaps most importantly, you will understand the genetic approaches; and you will appreciate their importance to the research.

Structure and function of Collagen types

Structure and function of Collagen types
  • Author : Richard Maynes
  • Publisher : Elsevier
  • Pages : 328
  • Relase : 2012-12-02
  • ISBN : 9780323155717

Structure and function of Collagen types Book Review:

Structure and Function of Collagen Types is a collection of articles that reviews the different types of collagens (Type I to XI). Each article focuses on a particular type of collagen and written by leading investigators in the collagen field. The book begins with a review of the fibril forming collagens (types I, II, and III) and traces the early work on the structure of these collagens to our knowledge of the structure of the collagen genes. This chapter is followed by a detailed description of type IV (basement membrane) collagen. Chapter 3 addresses the biosynthesis and chain assembly of type V collagen. The evidence that type VI collagen is assembled to form tetramers is presented in chapter 4. The subsequent article shows that type VII collagens are assembled to form partially overlapping dimers. Chapter 6 presents the structure of type VIII collagen. Chapters 7, 8, and 9 discuss the structure and characteristics of collagens that are synthesized by cartilaginous tissues and these are designated as type IX, type X, and type XI. The final chapter reviews the recombinant DNA techniques used to investigate collagen structure and the possibility to recognize new collagen types from a cDNA library. Physiologists, cell biologists, and researchers in the field of collagen will find the text very insightful.

Osteoarthritis

Osteoarthritis
  • Author : J.-Y. Reginster,J.-P. Pelletier,J. Martel-Pelletier,Y. Henrotin
  • Publisher : Springer Science & Business Media
  • Pages : 509
  • Relase : 2012-12-06
  • ISBN : 9783642600265

Osteoarthritis Book Review:

Musculoskeletal diseases are rapidly becoming a major health concern. The incidence of osteoarthritis, the most common arthritic disorder, is increasing steadily due to the graying of the world population. This disease is responsible of human life, a time in for significant morbidity, particularly in the second half which the quality of life is of primary importance. The aim of this publication is to bring to physicians and scientists a comprehensive overview of the field, from molecules to men. The direct costs related to osteoarthritis have been increasing steadily over the years and will soon be comparable to those of other major illnesses, such as cardiovascular diseases. This, of course, does not take into account all of the other costs related to the disease which often cannot be simply calculated in dollars and cents. There has been a great deal of renewed interest in osteoarthritis in the last few decades. This has been brought on by the need to improve our knowledge of all aspects of the disease, especially with regard to its etiopathogenesis and treatment. The most recent findings and developments on the structural, bio chemical, biomechanical and molecular changes observed in clinical and ex perimental osteoarthritis are presented in this book.

Sonography in Obstetrics and Gynecology

Sonography in Obstetrics and Gynecology
  • Author : Arthur C. Fleischer
  • Publisher : McGraw-Hill/Appleton & Lange
  • Pages : 1052
  • Relase : 1996
  • ISBN : 0838580424

Sonography in Obstetrics and Gynecology Book Review:

A comprehensive reference, this book covers all uses of ultrasound in obstetrics and gynecology. It is written by both radiologists and ob/ gyns, giving each specialty the perspective of the other. The text in cludes coverage of ultrasound diagnosis of prenatal anomalies as well as a complete atlas of hysterosalpinography. This new edition include s chapters on color Doppler sonography in pelvic pain, sonosalpinograp hy, ultrasound mini PACS, telesonography, and reporting systems.

Osteoarthritis

Osteoarthritis
  • Author : Roland W. Moskowitz
  • Publisher : Lippincott Williams & Wilkins
  • Pages : 492
  • Relase : 2007
  • ISBN : 0781767075

Osteoarthritis Book Review:

Written by the foremost experts, this text is a comprehensive clinical reference on osteoarthritis. Chapters review current information on the epidemiology, etiopathogenesis, and pathology of osteoarthritis, the biochemistry and molecular and cell biology of articular cartilage, and experimental models of osteoarthritis. Major sections focus on clinical presentations, roentgenologic and laboratory diagnosis, and treatment, including pharmacologic treatment, intra-articular therapy, surgery, arthroscopy, and complementary and alternative medicine. The authors discuss the indications, outcomes, and complications of various orthopaedic procedures. Chapters present orthopaedic approaches to osteoarthritis of various joints—the shoulder, hand, wrist, elbow, hip, knee, foot, ankle, and cervical, thoracic, and lumbar spine.

Extracellular Matrix Omics

Extracellular Matrix Omics
  • Author : Sylvie Ricard-Blum
  • Publisher : Springer
  • Pages : 225
  • Relase : 2021-12-17
  • ISBN : 3030583325

Extracellular Matrix Omics Book Review:

This book covers different omics aspects related to the extracellular matrix (ECM), namely specific omics resources focused on the extracellular matrix (e.g., databases, repositories and atlases), quantitative proteomics applied to specific extracellular matrices (e.g. basement membranes), biological processes such as ECM degradation (degradomics), cell-matrix interactions (adhesomes), signaling pathways, biomarker discovery and diseases, and interactomics (extracellular matrix interaction networks including not only protein-protein but also protein-glycosaminoglycan interactions). The volume also includes recent advances in glycomics and glycobioinformatics applied to proteoglycans and glycosaminoglycans, which are key biological players. The use of omics data to build dynamic models of ECM-regulated biological pathways is addressed, together with the requirement to standardize omic data, which is a prerequisite for the FAIR (Findability, Accessibility, Interoperability, and Reusability) guiding principles for scientific data management. This book will be of great interest to a broad readership from beginners to advanced researchers, who are interested in extracellular matrix omics and will inspire future research topics.

Cellular Mechanics and Biophysics

Cellular Mechanics and Biophysics
  • Author : Claudia Tanja Mierke
  • Publisher : Springer Nature
  • Pages : 900
  • Relase : 2020-10-30
  • ISBN : 9783030585327

Cellular Mechanics and Biophysics Book Review:

This book focuses on the mechanical properties of cells, discussing the basic concepts and processes in the fields of immunology, biology, and biochemistry. It introduces and explains state-of-the-art biophysical methods and examines the role of mechanical properties in the cell/protein interaction with the connective tissue microenvironment. The book presents a unique perspective on cellular mechanics and biophysics by combining the mechanical, biological, physical, biochemical, medical, and immunological views, highlighting the importance of the mechanical properties of cells and biophysical measurement methods. The book guides readers through the complex and growing field of cellular mechanics and biophysics, connecting and discussing research findings from different fields such as biology, cell biology, immunology, physics, and medicine. Featuring suggestions for further reading throughout and addressing a wide selection of biophysical topics, this book is an indispensable guide for graduate and advanced undergraduate students in the fields of cellular mechanics and biophysics.

Epigenetic Biomarkers and Diagnostics

Epigenetic Biomarkers and Diagnostics
  • Author : José Luis García-Giménez
  • Publisher : Academic Press
  • Pages : 696
  • Relase : 2015-12-07
  • ISBN : 9780128019214

Epigenetic Biomarkers and Diagnostics Book Review:

Epigenetic Biomarkers and Diagnostics comprises 31 chapters contributed by leading active researchers in basic and clinical epigenetics. The book begins with the basis of epigenetic mechanisms and descriptions of epigenetic biomarkers that can be used in clinical diagnostics and prognostics. It goes on to discuss classical methods and next generation sequencing-based technologies to discover and analyze epigenetic biomarkers. The book concludes with an account of DNA methylation, post-translational modifications and noncoding RNAs as the most promising biomarkers for cancer (i.e. breast, lung, colon, etc.), metabolic disorders (i.e. diabetes and obesity), autoimmune diseases, infertility, allergy, infectious diseases, and neurological disorders. The book describes the challenging aspects of research in epigenetics, and current findings regarding new epigenetic elements and modifiers, providing guidance for researchers interested in the most advanced technologies and tested biomarkers to be used in the clinical diagnosis or prognosis of disease. Focuses on recent progress in several areas of epigenetics, general concepts regarding epigenetics, and the future prospects of this discipline in clinical diagnostics and prognostics Describes the importance of the quality of samples and clinical associated data, and also the ethical issues for epigenetic diagnostics Discusses the advances in epigenomics technologies, including next-generation sequencing based tools and applications Expounds on the utility of epigenetic biomarkers for diagnosis and prognosis of several diseases, highlighting the study of these biomarkers in cancer, cardiovascular and metabolic diseases, infertility, and infectious diseases Includes a special section that discusses the relevance of biobanks in the maintenance of high quality biosamples and clinical-associated data, and the relevance of the ethical aspects in epigenetic studies

The Extracellular Matrix: an Overview

The Extracellular Matrix: an Overview
  • Author : Robert Mecham
  • Publisher : Springer Science & Business Media
  • Pages : 426
  • Relase : 2011-02-16
  • ISBN : 9783642165559

The Extracellular Matrix: an Overview Book Review:

Knowledge of the extracellular matrix (ECM) is essential to understand cellular differentiation, tissue development, and tissue remodeling. This volume of the series “Biology of Extracellular Matrix” provides a timely overview of the structure, regulation, and function of the major macromolecules that make up the extracellular matrix. It covers topics such as collagen types and assembly of collagen-containing suprastructures, basement membrane, fibronectin and other cell-adhesive glycoproteins, proteoglycans, microfibrils, elastin, fibulins and matricellular proteins, such as thrombospondin. It also explores the concept that ECM components together with their cell surface receptors can be viewed as intricate nano-devices that allow cells to physically organize their 3-D-environment. Further, the role of the ECM in human disease and pathogenesis is discussed as well as the use of model organisms in elucidating ECM function.

Lippincott's Illustrated Review of Biochemistry - Indian Edition

Lippincott's Illustrated Review of Biochemistry - Indian Edition
  • Author : Harvey
  • Publisher :
  • Pages :
  • Relase : 2004-11
  • ISBN : 078179983X

Lippincott's Illustrated Review of Biochemistry - Indian Edition Book Review:

The Extracellular Matrix and the Tumor Microenvironment

The Extracellular Matrix and the Tumor Microenvironment
  • Author : Ilona Kovalszky,Marco Franchi,Laura D. Alaniz
  • Publisher : Springer Nature
  • Pages : 494
  • Relase : 2022-08-07
  • ISBN : 9783030997083

The Extracellular Matrix and the Tumor Microenvironment Book Review:

This book introduces the most important and best studied extracellular and pericellular molecules of the tumor microenvironment. It gives a comprehensive overview of their role in tumor development and cancer progression. Twelve chapters deal with the biochemical and biophysical background of extracellular matrix (ECM) changes in the tumor stroma compared to the physiological state. The reader learns about the major ECM components that are deregulated during cancer development and how they are associated with cancer progression associated with survival, inflammation process, among others. These are followed by recent data about the cooperative activity of extracellular matrix in tumor metabolism, promoting cancer progression. Two chapters focus specifically on the critical role of the ECM in tumor angiogenesis, linking this process to cellular infiltration and metastatic behavior of tumors. The final part describes how the ECM influences the success of immuno- and chemotherapy in cancer patients, its potential as biomarkers for diagnosis, prognosis, and therapeutic target, as well as the mechanism of resistance-associated changes in the ECM. This book is an interesting read for anyone who want to know more about ECM and cancer biology. Early career scientists can use it as an introduction to the field, offering an excellent tool for studying ECM. Advanced researchers and clinicians can gain a broader overview of the subject, considering the role of ECM for influencing every cancer hallmark as well as in the response of cancer treatments. The work serves to inspire future research and shows that the ECM should be considered as an important factor in the development of cancer therapeutics. The series "Biology of Extracellular Matrix" is published in collaboration with the American Society for Matrix Biology and the International Society for Matrix Biology.

Interventional Neuroradiology of the Spine

Interventional Neuroradiology of the Spine
  • Author : Mario Muto
  • Publisher : Springer Science & Business Media
  • Pages : 259
  • Relase : 2013-09-12
  • ISBN : 9788847027909

Interventional Neuroradiology of the Spine Book Review:

Accurate interpretation of indications for treatment is the cornerstone of success in medicine. This book carefully examines the relation between clinical features, diagnosis, and choice of minimally invasive technique for a range of spine pathologies. It explains how selection of technique is intimately related to clinical and diagnostic aspects and how recognition of this relation forms the foundation for an optimal outcome. In addition to examining the various minimally invasive options, including the latest techniques, careful attention is paid to the role of medical treatment in avoiding recurrence after initial therapy. Nerve blocks, epidural injections, and intradiscal procedures are among the many options available in the armamentarium of the interventionalist, and advice is given on their use in different contexts. This volume will be of great value for neuroradiologists and others responsible for treating patients with spine disorders.

Extracellular Matrix in Development and Disease

Extracellular Matrix in Development and Disease
  • Author : Julia Oxford
  • Publisher :
  • Pages : 1
  • Relase : 2019
  • ISBN : 3038975710

Extracellular Matrix in Development and Disease Book Review:

The extracellular matrix in development and disease deals with the molecular and cellular aspects of development and disease. Cells exist in three-dimensional scaffolding called the extracellular matrix. The matrix holds together the millions of cells that make up our blood vessels, organs, skin, and all tissues of the body. The matrix serves as a reservoir of signaling molecules as well. In bacterial cultures, biofilms form as an extracellular matrix and play essential roles in disease and drug resistance. Topics such as matrix structure and function, cell attachment and cell surface proteins mediating cell-matrix interactions, synthesis, regulation, composition, structure, assembly, remodeling, and function of the matrix are included. A common thread uniting the topics is the essential nature that the matrix plays in normal development and pathophysiology. Providing new knowledge will lead us to improved diagnostics, the preventions of disease progression, and therapeutic strategies for the repair and regeneration of tissues. Topics such as the extracellular matrix in hereditary diseases, reproduction, cancer, muscle, and tissue engineering applications, and diverse roles for integrins, are included in this collection.

Dynamics of Bone and Cartilage Metabolism

Dynamics of Bone and Cartilage Metabolism
  • Author : Markus J. Seibel,Simon P. Robins,John P. Bilezikian
  • Publisher : Elsevier
  • Pages : 920
  • Relase : 2006-07-24
  • ISBN : 008045626X

Dynamics of Bone and Cartilage Metabolism Book Review:

This updated edition is a comprehensive treatise that spans the complete range of basic biochemistry of bone and cartilage components to the clinical evaluation of disease markers in bone and joint disorders. With contributions from over 75 international experts, Dynamics of Bone and Cartilage Metabolism, Second Edition, is indispensable reading for those involved in skeletal research as well as for rheumatologists, endocrinologists, clinical biochemists, and other clinical disciplines participating in the management of patients with bone and cartilage diseases. Part I provides an up-to-date account of current knowledge of the structure, biosynthesis and molecular biology of the major tissue components Part II covers the organizational structure and cellular metabolism of bone and cartilage Part III deals with the utility of components specific to bone and cartilage as biomarkers of health and disease

Extracellular Matrix in Development and Disease

Extracellular Matrix in Development and Disease
  • Author : Jeffrey H. Miner
  • Publisher : Elsevier
  • Pages : 233
  • Relase : 2005-12-02
  • ISBN : 0444518460

Extracellular Matrix in Development and Disease Book Review:

Extracellular matrix proteins are serious, common human diseases that are caused by mutations in genes that encode these proteins. This has spurred a great number of researchers to study the extracellular matrix, sometimes by choice and sometimes by necessity. Much progress has been made in the last decade towards understanding what matrix proteins do and how cells interact with and respond to them. Volume 15 is a compilation of reviews by experts in their respective fields. The chapters in this book address the biology of a broad spectrum of extracellular matrix molecules and their functions in development and disease. This book has been designed to focus on a diverse subset of matrix proteins that have been shown to be important for development, function, and disease. The book therefore both presents a broad view of the field and provides crucial details about some of the best-studied matrix molecules. * Written by leaders in the field * Discusses the potential of matrix components to be used as therapeutic tools for the treatment and prevention of cancer * Offers a section on integrin signaling and the development of the central nervous system, detailing the migration of neurons and the glia * Covers a diverse array of molecules such as laminins, collagens, heparan sulfate proteoglycans, integrins, and more

Extracellular Matrix in Development

Extracellular Matrix in Development
  • Author : Douglas W. DeSimone,Robert Mecham
  • Publisher : Springer Science & Business Media
  • Pages : 253
  • Relase : 2013-03-15
  • ISBN : 9783642359354

Extracellular Matrix in Development Book Review:

Cells in the developing embryo depend on signals from the extracellular environment to help guide their differentiation. An important mediator in this process is the extracellular matrix – secreted macromolecules that interact to form large protein networks outside the cell. During development, the extracellular matrix serves to separate adjacent cell groups, participates in establishing morphogenic gradients, and, through its ability to interact directly will cell-surface receptors, provides developmental clocks and positional information. This volume discusses how the extracellular matrix influences fundamental developmental processes and how model systems can be used to elucidate ECM function. The topics addressed range from how ECM influences early development as well as repair processes in the adult that recapitulate developmental pathways.

Biochemistry of Collagens, Laminins and Elastin

Biochemistry of Collagens, Laminins and Elastin
  • Author : Morten Karsdal
  • Publisher : Academic Press
  • Pages : 272
  • Relase : 2016-07-29
  • ISBN : 9780128098998

Biochemistry of Collagens, Laminins and Elastin Book Review:

Biochemistry of Collagens, Laminins, and Elastin: Structure, Function, and Biomarkers provides a comprehensive introduction to collagen and structural proteins. Type I collagen is one of the most abundant molecules in the body, playing essential roles in different tissues, particularly bone and skin. A key aspect of type I collagen is its post-translational modifications which are essential for correct synthesis and structural integrity of collagens, for tissue-specific functionality, as well as for application as biomarkers of different pathologies. This volume summarizes current data on key structural proteins (collagens, laminins and elastin), reviews how these molecules affect pathologies, and describes selected modifications of proteins that result in altered signaling properties of the original extracellular matrix component. Further, it discusses the novel concept that an increasing number of components of the ECM harbor cryptic signaling functions that may be viewed as endocrine functions. Additionally, it highlights how this knowledge can be exploited to modulate fibrotic disease. Provides a comprehensive introduction to collagen and structural proteins Provides insight into emerging analytical technologies that can detect biomarkers of extracellular matrix degradation Includes a chapter dedicated to the biomarkers of structural proteins Contains insights into the biochemical interactions and changes to structural composition of proteins in disease states

Thoraco-Abdominal Aorta

Thoraco-Abdominal Aorta
  • Author : Roberto Chiesa,Germano Melissano,Alberto Zangrillo
  • Publisher : Springer Science & Business Media
  • Pages : 760
  • Relase : 2011-03-15
  • ISBN : 9788847018570

Thoraco-Abdominal Aorta Book Review:

The thoraco-abdominal aortic pathology is not uncommon and represents the ultimate challenge for vascular surgeons. The book deals with the newest endovascular and hybrid approaches, together with more traditional surgical strategies. Written by internationally renowned experts in vascular and cardiac surgery, anesthesiology and radiology, the volume provides a very practical approach to the main problems encountered from diagnosis to postoperative care: general principles of aortic diseases, imaging techniques, surgical and anesthesiologic strategies and techniques and other specific problems are some of the topic dealt with. Numerous pictures illustrate the most important diagnostic findings and depict key techniques and strategies. Vascular and cardiac surgeons, anesthesiologists, perfusionists and radiologists will find in this volume useful and updated information for the treatment of this very challenging condition.

Cumulated Index Medicus

Cumulated Index Medicus
  • Author : Anonim
  • Publisher :
  • Pages : 1516
  • Relase : 1994
  • ISBN : OSU:32436010002036

Cumulated Index Medicus Book Review: